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    5142-23-4

    Catalog No. EBD59

    CAS 5142-23-4

    Name 3-Methyl-3H-purin-6-amine

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    Basic Information

    Synonyms: 3-methyl-3H-adenine 3-Methyladenine 5-26-17-00151(BeilsteinHandbookReference) BRN0146087 NSC66389 3H-Purin-6-amine,3-methyl- Adenine,3-methyl- 3-methyl-3H-purin-6-amine 3-MA

    Molecular Formula: C6H7N5

    Molecular Weight: 149.15

    MDL Number: MFCD00010531

    Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    6-Amino-3-methylpurine is a purine derivative characterized by an amino group at the 6-position and a methyl group at the 3-position of the purine ring system. It serves as a key synthetic precursor and building block for various nucleoside analogs and modified purine bases. Its primary application is in medicinal chemistry and biochemistry research. It is used as an intermediate in the synthesis of biologically active compounds, including potential antiviral and anticancer agents. For instance, it is a crucial starting material for preparing 3-methyladenine (3-MA), a well-known autophagy inhibitor used extensively in cell biology studies to investigate autophagy pathways. The compound's structure allows for further functionalization to create novel nucleoside derivatives for pharmaceutical development. As a modified purine base, it finds utility in studying nucleic acid chemistry and enzyme interactions. Its properties make it a valuable tool for probing the structure-activity relationships of purine-based drugs and biochemical probes.
    Physical Properties

    Melting Point: ~300 °C (dec.)(lit.)

    mg g kg ml l t