6-Chloronicotinic acid, CAS No. 5326-23-8

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5326-23-8

Catalog No. EBD21413

CAS 5326-23-8

Name 6-Chloronicotinic acid

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Basic Information

Synonyms: 6-Chloronicotinicacid 6-chloro-3-pyridinecarboxylicacid 6-Chloropyridine-3-carboxylicacid 3-Pyridinecarboxylicacid,6-chloro- 6-chloropyridine-3-carboxylate RARECHEMALBO0729 TIMTEC-BBSBB004004 6-chloro-nicotinicacid

Molecular Formula: C6H4ClNO2

Molecular Weight: 157.55

MDL Number: MFCD00006241

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

6-Chloropyridine-3-carboxylic acid is an organic compound featuring a pyridine ring substituted with a chlorine atom at the 6-position and a carboxylic acid group at the 3-position. It serves as a versatile and important heterocyclic building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). For instance, it is a crucial precursor in the manufacturing of Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor used for the treatment of type 2 diabetes. The molecule's structure allows for further functionalization, making it valuable for constructing more complex heterocyclic systems found in drug candidates. As a bifunctional molecule containing both a halogen and a carboxylic acid, it is amenable to a range of chemical transformations, including cross-coupling reactions and amide bond formations. This reactivity profile solidifies its role not only as a specialized pharmaceutical intermediate but also as a general synthetic building block in medicinal chemistry research.

Physical Properties

Melting Point: 190 °C (dec.)(lit.)

Boiling Point: 330.1 °C at 760 mmHg

Flash Point: 192°C

Density: 0.5

Analytical Data

Appearance: Off-white to beige crystalline powder