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    617718-46-4

    Catalog No. EBD489784

    CAS 617718-46-4

    Name 3-fluoroazetidine hydrochloride

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    Basic Information

    Synonyms: 3-Fluoroazetidinehydrochloride 3-Fluorazetidinhydrochlorid(1:1) 3-Fluoroazetidinehydrochloride(1:1) Azetidine,3-fluoro-,hydrochloride(1:1) 3-FluoroazetidineHCl 3-fluoroazetidine hydrochloride

    Molecular Formula: C3H7ClFN

    Molecular Weight: 111.55

    MDL Number: MFCD05663715

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    3-Fluoroazetidine hydrochloride is a versatile organic building block characterized by its saturated, three-membered azetidine ring substituted with a fluorine atom at the 3-position, supplied as its hydrochloride salt. This structure combines the high reactivity and ring strain of the azetidine heterocycle with the unique electronic and steric properties imparted by the fluorine atom. Its primary and most significant application is in medicinal chemistry as a key intermediate for the synthesis of novel pharmaceutical compounds. The fluorinated azetidine moiety is a valuable scaffold for constructing bioactive molecules, particularly in the development of kinase inhibitors and other targeted therapies. The fluorine atom can enhance metabolic stability, influence lipophilicity, and engage in specific interactions with biological targets. As a synthetic intermediate, it is used to introduce the 3-fluoroazetidine group into larger molecular architectures, serving as a crucial step in the synthesis of potential drug candidates. The compound is typically handled under inert atmosphere due to the sensitivity of the strained ring and the hydrochloride salt form. It is commercially available for research and development purposes, primarily targeting the synthesis of complex molecules in drug discovery programs.
    Physical Properties

    Boiling Point: 59.3 °C at 760 mmHg

    mg g kg ml l t