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    64182-61-2

    Catalog No. EBD35025

    CAS 64182-61-2

    Name 2-Chloro-6-fluoronitrobenzene

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    Basic Information

    Synonyms: 2-Chloro-6-fluoronitrobenzene 1-Chloro-3-fluoro-2-nitrobenzene 264-723-5

    Molecular Formula: C6H3ClFNO2

    Molecular Weight: 175.54

    MDL Number: MFCD06658264

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    2-Chloro-6-fluoronitrobenzene is an aromatic compound featuring a nitro group and two different halogen substituents (chlorine and fluorine) on the benzene ring. This specific substitution pattern makes it a versatile and valuable building block in organic synthesis. Its primary application is as a key intermediate in the pharmaceutical industry. It serves as a crucial starting material for the synthesis of various active pharmaceutical ingredients (APIs) and complex heterocyclic compounds. For instance, it is a known precursor in the synthesis of fluoroquinolone antibiotics, such as fleroxacin and other related antibacterial agents. The presence of both electron-withdrawing groups (nitro and halogens) activates the ring for nucleophilic aromatic substitution reactions, allowing for the sequential introduction of other functional groups like amines. This compound is a solid at room temperature and requires careful handling due to its potential toxicity and irritant properties. It is typically used in controlled laboratory and industrial settings for the preparation of more complex, biologically active molecules.
    Physical Properties

    Boiling Point: 245.1 °C at 760 mmHg

    Flash Point: 102 °C

    Density: 1.494 g/cm3

    mg g kg ml l t