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    6452-47-7

    Catalog No. EBD10098

    CAS 6452-47-7

    Name chloro(methyl)carbamic acid

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    Basic Information

    Synonyms: 甲胺基甲酰氯 甲氨基甲酰氯

    Molecular Formula: C2H4ClNO

    Molecular Weight: 9351.0

    MDL Number: MFCD08703300

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Organic Building Blocks > Special Functional Group Blocks

    Product Description:
    Chloro(methyl)carbamic acid is a reactive carbamoyl chloride derivative featuring a methylamino group and a chloroformyl moiety. It is primarily utilized as a versatile acylating and carbamoylating agent in organic synthesis, particularly for introducing the N-methylcarbamate functional group into target molecules. In the pharmaceutical industry, it serves as a key intermediate for the synthesis of certain carbamate-containing drug candidates and agrochemicals, where it facilitates the formation of carbamate linkages under mild conditions. Its high reactivity toward nucleophiles (e.g., amines, alcohols) makes it valuable for constructing bioactive compounds. Due to its corrosive and moisture-sensitive nature, this compound requires careful handling under inert atmospheres. It is commonly employed in research laboratories for building small-molecule libraries and in process chemistry for scale-up of carbamate-based active ingredients.
    Physical Properties

    Melting Point: 45°C

    Boiling Point: 93°C (dec.)

    Density: 1.185 g/cm3

    mg g kg ml l t