tert-Butyl (4-aminobutyl)carbamate, CAS No. 68076-36-8

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68076-36-8

Catalog No. EBD12215

CAS 68076-36-8

Name tert-Butyl (4-aminobutyl)carbamate

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Basic Information

Synonyms: N-boc-1,4-diaminobutane N-(4-Aminobutyl)carbamicacidtert-butylester N-Boc-1,4-butanediamine tert-butyl(4-aminobutyl)carbamate 4-[(tert-butoxycarbonyl)amino]butan-1-aminium tert-butyl4-aminobutylcarbamate tert-ButylN-(4-aminobutyl)carbamate

Molecular Formula: C9H20N2O2

Molecular Weight: 188.27

MDL Number: MFCD00210019

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-1,4-butanediamine is a protected diamine compound featuring a tert-butoxycarbonyl (Boc) group on one of its primary amine functionalities. This protection renders the Boc-protected amine stable under basic conditions and inert to many nucleophiles, while the remaining free primary amine remains reactive. It is a white to off-white crystalline solid or powder. This compound is a versatile and crucial building block in organic synthesis, particularly in medicinal chemistry and peptide chemistry. Its primary application is as a key intermediate for the synthesis of various biologically active molecules, including pharmaceutical candidates and peptide mimetics. The free amine can be used for amide bond formation or other coupling reactions, while the Boc group can be selectively removed under acidic conditions (e.g., TFA) to reveal the second primary amine, allowing for sequential and controlled synthesis. As a bifunctional linker, it is instrumental in constructing molecular scaffolds, spacers, and conjugates. It is also used in the synthesis of polyamines, dendrimers, and materials science applications. Proper handling is required as it may cause skin and eye irritation.

Physical Properties

Boiling Point: 292.872 °C at 760 mmHg

Flash Point: 109 °C

Density: 0.984 g/mL at 20 °C(lit.)

Refractivity: n20/D 1.460

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 2735PSN2