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    69627-03-8

    Catalog No. EBD16243

    CAS 69627-03-8

    Name 7-Chlorothieno[3,2-b]pyridine

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    Basic Information

    Synonyms: 7-Chlorothieno[3,2-b]pyridine 7-Chlorthieno[3,2-b]pyridin Thieno[3,2-b]pyridine,7-chloro- N-(tert-Butoxycarbonyl)-L-prolinal (S)-tert-Butyl2-formylpyrrolidine-1-carboxylate 2-Formylpyrrolidine-1-carboxylicacidtert-butylester

    Molecular Formula: C7H4ClNS

    Molecular Weight: 169.63

    MDL Number: MFCD08448161

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    7-Chlorothieno[3,2-b]pyridine is a bicyclic heteroaromatic compound featuring a fused thiophene and pyridine ring system with a chlorine substituent at the 7-position. This specific substitution pattern makes it a valuable and versatile chemical building block, particularly in medicinal chemistry. Its primary and most significant application is as a key synthetic intermediate in the development of pharmaceutical agents. The thienopyridine scaffold is a privileged structure in drug discovery, known for imparting favorable pharmacological properties. This specific chlorinated derivative serves as a crucial precursor for the synthesis of various biologically active molecules, including kinase inhibitors and other targeted therapeutics. The chlorine atom acts as a reactive handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) or nucleophilic aromatic substitution, allowing for the rapid generation of diverse compound libraries for biological screening. As a specialized heterocyclic synthon, it is primarily utilized in research and development settings rather than as a bulk commodity. Its value lies in enabling efficient access to complex molecular architectures relevant to modern drug discovery programs.
    Physical Properties

    Boiling Point: 257.5 °C at 760 mmHg

    Flash Point: 109.5 °C

    Density: 1.435 g/cm3

    mg g kg ml l t