N-Cbz-ethylenediamine hydrochloride, CAS No. 72080-83-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

72080-83-2

Catalog No. EBD11181

CAS 72080-83-2

Name N-Cbz-ethylenediamine hydrochloride

Get Quote

Basic Information

Synonyms: Carbamicacid,N-(2-aminoethyl)-,phenylmethylester Carbamicacid,(2-aminoethyl)-,benzylester Carbamicacid,(2-aminoethyl)-,phenylmethylester (2-Aminoethyl)carbamicacidbenzylester 1-(Benzyloxycarbonylamino)-2-aminoethane BenzylN-(2-aminoethyl)carbamate Mono(benzyloxycarbonyl)ethylenediamine N-(2-Aminoethyl)carbamicacidbenzylester N-(Benzyloxycarbonyl)-1,2-diaminoethane N-Benzyloxycarbonyl-1,2-ethanediamine N-Benzyloxycarbonylethylenediamine N-Cbz-ethylenediaminehydrochloride

Molecular Formula: C10H15ClN2O2

Molecular Weight: 230.69

MDL Number: MFCD00270150

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-CBZ-1,2-diaminoethane is a protected diamine derivative, specifically featuring a benzyloxycarbonyl (Cbz) protecting group on one of the primary amine functionalities of ethylenediamine. This compound is a white to off-white crystalline powder. Its primary application is as a versatile building block in organic synthesis, particularly in the pharmaceutical industry for the preparation of active pharmaceutical ingredients (APIs) and complex molecules. The Cbz group serves as a robust amine protecting group that is stable under a variety of reaction conditions but can be selectively removed via catalytic hydrogenation or acidic treatment (e.g., HBr/AcOH). This makes it a crucial intermediate for the synthesis of diamines, heterocycles, and peptide mimetics, which are core structures in many drug candidates. As a bifunctional molecule, it is used to introduce an ethylenediamine spacer or linker into target compounds. It finds utility in the synthesis of kinase inhibitors, antimicrobial agents, and other bioactive molecules. Handling requires standard precautions for laboratory chemicals, avoiding inhalation and contact with skin or eyes.

Physical Properties

Melting Point: 169-172 ºC(lit.)