2,2,2-Trifluoroethanol, CAS No. 75-89-8

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75-89-8

Catalog No. EBD16073

CAS 75-89-8

Name 2,2,2-Trifluoroethanol

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Basic Information

Synonyms: Trifluoroethanol Trifluroroethylalchohol 1,1,2-trifluoroethanol chloro(difluoro)aceticacid 2,2,2-Trifluoroethanol

Molecular Formula: C2H3F3O

Molecular Weight: 100.04

MDL Number: MFCD00004672

Product Description:

2,2,2-Trifluoroethanol (TFE, CAS 75-89-8) is a colorless, volatile liquid with the molecular formula CF_CH_OH. It is a fluorinated alcohol characterized by a strong electron-withdrawing trifluoromethyl group, which imparts high acidity (pKa б╓ 12.4) and polarity, making it a versatile solvent and reagent. TFE is widely used as a solvent in peptide chemistry and protein folding studies due to its ability to stabilize secondary structures like ж┴-helices. In organic synthesis, it serves as a key building block for pharmaceuticals (e.g., anesthetics like isoflurane intermediates) and agrochemicals. It also acts as a reaction medium for oxidative transformations and as a co-solvent in lithium-ion battery electrolytes to enhance stability. Additionally, TFE is employed in the production of fluorinated surfactants and polymers. It is flammable and toxic if ingested, requiring careful handling. Its unique solvation properties make it indispensable in both academic research and industrial applications.

Physical Properties

Melting Point: −44 °C(lit.)

Boiling Point: 77-80 °C(lit.)

Flash Point: 29 °C

Density: 3.5 (vs air)

Solubility: Misible soluble with water

Refractivity: n20/D 1.3(lit.)

Storage: Store at RT.

Safety Information

Packing Level: III

Hazard Category: 6.1(3)

Transport Codes: 1986

Analytical Data

Appearance: colorless liquid