Fludarabine phosphate, CAS No. 75607-67-9

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

75607-67-9

Catalog No. EBD3286

CAS 75607-67-9

Name Fludarabine phosphate

Get Quote

Basic Information

Synonyms: 9-bata-D-Arabinofuranosyl-2-fluoroadeninephosphate Fludarabinephosphate FludarabinPhosphate 9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogenphosphate) 9-b-D-Arabinofuranosyl-2-fluoroadenine5￠-(dihydrogenphosphate) 2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine Fludarabine 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Fluoro-9-(5-O-phosphono-β-D-arabinof

Molecular Formula: C10H13FN5O7P

Molecular Weight: 365.21

MDL Number: MFCD00866418

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

Fludarabine phosphate is a fluorinated purine nucleoside analog and the phosphate salt of fludarabine. It is a prodrug that is rapidly dephosphorylated in plasma to its active metabolite, fludarabine arabinoside 2-fluoro-ara-A (F-ara-A), which is subsequently phosphorylated intracellularly to the active triphosphate form (F-ara-ATP). This compound is a potent antineoplastic agent primarily used in the treatment of hematologic malignancies. Its main mechanism of action involves inhibition of DNA synthesis. F-ara-ATP competitively inhibits DNA polymerases, ribonucleotide reductase, and DNA primase, leading to termination of DNA chain elongation and induction of apoptosis in rapidly dividing cells. It is a key chemotherapeutic drug for chronic lymphocytic leukemia (CLL) and is also used in conditioning regimens prior to hematopoietic stem cell transplantation. Fludarabine phosphate is administered intravenously due to its poor oral bioavailability. It is associated with significant immunosuppression, increasing the risk of opportunistic infections, and requires careful patient monitoring. Its development and use represent a significant advancement in the treatment of lymphoid cancers.

Physical Properties

Boiling Point: 864.2 °C at 760 mmHg

Flash Point: 476.4 °C

Density: 2.39 g/cm3