2-Methyl-2-phenylpropionic acid, CAS No. 826-55-1

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826-55-1

Catalog No. EBD15743

CAS 826-55-1

Name 2-Methyl-2-phenylpropionic acid

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Basic Information

Synonyms: 2-methyl-2-phenylpropanoicacid 2-Phenylisobutyricacid alpha,alpha-DimethylphenylAceticAcid α,α-Dimethylphenylaceticacid a,a-DimethylPhenylAceticAcid 2-methyl-2-phenylpropanoate 2-Methyl-2-phenylpropionicacid

Molecular Formula: C10H12O2

Molecular Weight: 164.2

MDL Number: MFCD00014332

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

2-Methyl-2-phenylpropionic acid is a branched aromatic carboxylic acid featuring a quaternary carbon center adjacent to a phenyl ring. Its structure combines a sterically hindered carboxylic acid group with a hydrophobic phenyl moiety, making it a valuable building block in medicinal chemistry. This compound is primarily utilized as a small-molecule drug fragment and synthetic intermediate in the development of pharmaceuticals, particularly for constructing non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. The steric bulk of the gem-dimethyl group can influence molecular conformation and metabolic stability. Additionally, it serves as a versatile organic synthesis building block, functioning as a carboxylic acid donor in esterification and amidation reactions. Its unique structure also makes it useful in the synthesis of chiral auxiliaries and specialty polymers. Standard safety precautions for handling carboxylic acids should be observed.

Physical Properties

Melting Point: 80-82°C

Boiling Point: 146.5°C

Flash Point: 146.5°C

Density: 1.089 g/cm3

Solubility: Insoluble in water

Analytical Data

Appearance: White crystalline