(R)-3-(1-(Dimethylamino)ethyl)phenol, CAS No. 851086-95-8

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851086-95-8

Catalog No. EBD765

CAS 851086-95-8

Name (R)-3-(1-(Dimethylamino)ethyl)phenol

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Basic Information

Synonyms: ENT NAP 226-90 (R)-3-(1-(DIMETHYLAMINO)ETHYL)PHENOL 3-[(1R)-1-(Dimethylamino)ethyl]phenol (R)-3-1(-DIMETHYLAMINO)ETHYLPHENOL 3-[(1R)-1-(Dimethylaminoethyl)]phenol (R)-3-1-(Dimethylamino)ethylphenol 3-((R)-1-Dimethylamino-ethyl)phenol entnap226-90 (r)-3-(1-n,n-dimethylaminoethyl)]phenol phenol,3-[(1r)-1-(dimethylamino)ethyl]-

Molecular Formula: C10H15NO

Molecular Weight: 165.23

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-[(1R)-1-(Dimethylamino)ethyl]phenol is a chiral phenolic compound featuring a dimethylaminoethyl substituent at the meta position of the benzene ring. It is a key chiral intermediate in the synthesis of various pharmaceutical agents. This compound is notably utilized in the preparation of (R)-tolterodine, a potent muscarinic receptor antagonist used for the treatment of overactive bladder. Its chiral structure is crucial for the biological activity of the final drug product. The presence of both phenolic and tertiary amine functional groups makes it a versatile building block for constructing more complex molecules through further chemical modifications. As a chiral amine derivative, it serves as a valuable synthon in asymmetric synthesis and medicinal chemistry research.

Physical Properties

Boiling Point: 241.3 °C at 760 mmHg

Flash Point: 97.2 °C

Density: 1.021 g/cm3