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    86869-14-9

    Catalog No. EBD50615

    CAS 86869-14-9

    Name 2-Cyano-5-hydroxypyridine

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    Basic Information

    Synonyms: 5-hydroxypyridine-2-carbonitrile 5-hydroxypicolinonitrile,2-cyano-5-hydroxypyridine,6-cyanopyridin-3-ol 5-hydroxypicolinonitrile

    Molecular Formula: C6H4N2O

    Molecular Weight: 120.11

    MDL Number: MFCD07368197

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    2-Cyano-5-hydroxypyridine is a heterocyclic organic compound featuring a pyridine ring substituted with a cyano group at the 2-position and a hydroxyl group at the 5-position. This structure makes it a versatile bifunctional building block, containing both an electron-withdrawing cyano group and a phenolic hydroxyl group. Its primary application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various biologically active molecules, particularly in the development of kinase inhibitors and other therapeutic agents. The compound's reactive sites allow for further functionalization, enabling the construction of complex heterocyclic scaffolds common in modern drug discovery. While its main use is in medicinal chemistry, its well-defined structure also qualifies it as a specialized organic synthesis building block, particularly within the category of cyano-containing compounds. It is typically handled as a solid and requires standard laboratory safety precautions for handling fine chemicals.
    Physical Properties

    Boiling Point: 429.228 °C at 760 mmHg

    Flash Point: 213.39 °C

    Density: 1.332 g/cm3

    mg g kg ml l t