2-Methylthiopyrimidine-5-carboxaldehyde, CAS No. 90905-31-0

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90905-31-0

Catalog No. EBD422865

CAS 90905-31-0

Name 2-Methylthiopyrimidine-5-carboxaldehyde

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Basic Information

Synonyms: 2-Methylthiopyrimidine-5-carboxaldehyde 2-methylthiopyrimidine-5-carbaldehyde 5-formyl-2-methylthiopyrimidine 2-methylsulfanyl-pyrimidine-5-carbaldehyde 2-methylthio-5-pyrimidinecarbaldehyde 2-(Methylthio)pyrimidine-5-carbaldehyde 2-methylsulfanylpyrimidine-5-carbaldehyde asinex-reagbas05215236 asischemc63389 chembrdg-bb4010269 2-methylsulfonylpyrimidine-5-carbaldehyde 2-methylsulfanyl-pyrimidine-5-carbaldehyde,95% 2-(methylthio)pyrimidine-5-carboxaldehyde

Molecular Formula: C6H6N2OS

Molecular Weight: 154.19

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

2-(Methylthio)pyrimidine-5-carbaldehyde is an organic compound featuring a pyrimidine ring substituted with a formyl group at the 5-position and a methylthio group at the 2-position. This structure makes it a versatile heterocyclic aldehyde building block. Its primary and most significant application is in pharmaceutical research and development as a key synthetic intermediate. The aldehyde group is a highly reactive handle for constructing more complex molecules via condensation reactions (e.g., forming imines, oximes, or undergoing reductive amination) or for building fused heterocyclic systems. It is notably utilized in the synthesis of various biologically active compounds, including kinase inhibitors and other potential therapeutic agents targeting specific disease pathways. As a bifunctional molecule containing both a heterocyclic core and an aldehyde, it serves as a crucial precursor in medicinal chemistry for introducing the pyrimidine pharmacophore into target structures. Its utility extends into material science for constructing organic semiconductors, though its primary industrial relevance remains in fine chemical synthesis for active pharmaceutical ingredients (APIs) and advanced intermediates.

Physical Properties

Boiling Point: 301.214 °C at 760 mmHg

Flash Point: 135.97 °C

Density: 1.29 g/cm3