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    96293-19-5

    Catalog No. EBD15285

    CAS 96293-19-5

    Name NI-(S)-BPB-GLY

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    Basic Information

    Synonyms: NI-(S)-BPB-GLY (s)-(o-(N-benzylprolyl)amino)(phenyl)methyleneiminoacetate (s)-o-[(n-benzylprolyl)amino](phenyl)methyleneiminoacetate(2)-n,n',n''-nickel(ii) ni-(s)-bpb-gly,99% ni-(s)-bpb-gly(s)-[o-[(n-benzylprolyl)amino](phenyl)methyleneiminoacetate(2-)-n,n',n''-nickel(ii) (s)-(o-(n-benzylprolyl)amino)(phenyl) (s)-2-{o-{(n-benzylprolyl)amino}phenyl}-benzylideneamino-acetato(2-)-n,n',n''-nickel(ii)

    Molecular Formula: C27H25N3NiO3

    Molecular Weight: 498.2

    Categories: Medicinal Chemistry > Targeted Protein Degradation Tools > Linkers Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    The compound with CAS 96293-19-5 is a chiral amino acid derivative, specifically (S)-O-(N-Benzylprolyl)amino(phenyl)acetonitrile. Its structure features a proline core modified with a benzyl group and linked to a phenylacetonitrile moiety via an O-alkylamino bridge. This specific scaffold is a key intermediate in the synthesis of more complex molecules. Its primary and most significant application is in the field of targeted protein degradation (TPD), particularly in the development of Proteolysis-Targeting Chimeras (PROTACs). This compound serves as a versatile **linker** component. The proline-based structure provides a rigid, chiral backbone that can effectively connect an E3 ligase ligand (often based on a VHL or CRBN binder) to a target protein ligand, influencing the overall geometry and pharmacokinetic properties of the final PROTAC degrader. Due to its defined chiral center and functional groups (amine, nitrile), it also functions as a specialized **organic synthetic building block** for constructing peptide mimetics and other pharmacologically active scaffolds beyond PROTACs. Its synthesis and use require handling under inert conditions due to potential sensitivity.
    Physical Properties

    Melting Point: 219-222 °C

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